(Intravenous Immunoglobulin [IVIg; IgG])
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Reasons for Procedure
- Autoimmune disease—the body begins to attack its own cells
- Immunodeficiency—low-functioning immune system
- Inflammatory diseases
- Other diseases that weaken the immune system
- Fluid in the lungs
- Damage to the kidneys
- Blood clots
- Allergic reaction to the IVIg
What to Expect
Prior to Procedure
Description of the Procedure
How Long Will It Take?
Will It Hurt?
Call Your Doctor
- Wheezing and/or difficulty breathing
- Slurred or abnormal speech
- Rapid heartbeat or heart palpitations, weak or rapid pulse
- Blue tint to the skin, lips, or fingernails
- Dizziness, lightheadedness, or feeling faint
- Hives, rash, or itching
- Nausea, vomiting, diarrhea, or abdominal cramping
- Cough or nasal congestion
- Reddened skin
National Library of Medicine http://www.nlm.nih.gov
British Columbia Ministry of Health http://bchealthguide.org
Canadian AIDS Society http://www.cdnaids.ca
Adverse effects of intravenous immunoglobulin therapy. American Academy of Allergy Asthma & Immunology website. Available at: http://www.aaaai.org/aad mc/currentliterature/selectedarticles/2003archive/intravenous%5Fimmunoglobulin.html. Accessed May 27, 2007.
Darabi, K, Abdel-Wahab, O, et al. Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature. Transfusion. 2006; 46:741.
Emerson GG, Herndon CN, et al. Pharmacotherapy. 2002;22(12):1638-1641.
Nydegger UE. Safety and side effects of IV immunoglobulin therapy. Clin Exp Rheum. 1996;14(suppl 15):S53-57.
Orange, JS, Hossny, EM, et al. Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol. 2006; 117:S525.
Sherer Y, Levy Y, et al. Intravenous immunoglobulin therapy of antiphospholipid syndrome. Rheumatology. 2000;39:421-426. Available at http://rheumatology.oxfordjournals.org/cgi/content/full/39/4/421. Accessed May 28, 2007.
- Reviewer: Igor Puzanov, MD
- Review Date: 11/2012 -
- Update Date: 05/11/2013 -