Interactions You Should Know About
- Drugs in the benzodiazepine family: Pregnenolone may decrease their effectiveness.
1 Meldrum DR, Davidson BJ, Tataryn IV, et al. Changes in circulating steroids with aging in postmenopausal women. Obstet Gynecol . 1981;57:624-628.
2 Flood JF, Morley JE, Roberts E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc Natl Acad Sci USA . 1995;92:10806-10810.
3 Flood JF, Morley JE, Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci U S A . 1992;89:1567-1571.
4 Meieran SE, Reus VI, Webster R, et al. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology . 2004;29:486-500.
- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013 -
- Update Date: 08/22/2013 -