What Is Goldenseal Used for Today?
- There is no credible evidence that goldenseal increases immunity. Only one study weakly hints at an immune strengthening effect. 19
- Colds are caused by viruses and don't respond to antibiotics, even if goldenseal were an effect systemic (whole body) antibiotic, which it almost certainly isn't.
- Goldenseal was never used traditionally for the common cold.
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18 Yesilada E, Kupeli E. Berberis crataegina DC. root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats. J Ethnopharmacol . 2002;79:237-248.
19 Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis . Immunol Lett. 1999;68:391-395.
20 Inbaraj JJ, Kukielczak BM, Bilski P, et al. Photochemistry and photocytotoxicity of alkaloids from Goldenseal ( Hydrastis canadensis L. ). Chem Res Toxicol. 2001;14:1529-1534.
21 Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med . 2004 Nov 07 [Epub ahead of print]
22 Wu X, Li Q, Xin H et al. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol . 2005 Aug 26 [Epub ahead of print].
23 Gurley BJ, Swain A, Hubbard MA, et al. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and echinacea. Mol Nutr Food Res. 2008 Jan 23.
24 Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008 Apr 8.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -