What Is Cayenne Used for Today?
What is the Scientific Evidence for Cayenne?
Oral Uses of Cayenne
Topical Uses of Cayenne
- Post-herpetic neuropathy (the pain that lingers after an attack of shingles) 14-16,37
- Peripheral neuropathy (nerve pain that occurs most commonly as a complication of diabetes , but may occur with HIV as well as other conditions) 1,17-23,35
- Pain after cancer surgery24-27 or hernia repair 36
Intranasal Uses of Cayenne for Rhinitis
Interactions You Should Know About
1 McCleane G. Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol . 2000;49:574-579.
2 Deal CL, Schnitzer TJ, Lipstein E, et al. Treatment of arthritis with topical capsaicin: A double blind trial. Clin Ther . 1991;13:383-395.
3 McCarthy GM, McCarty DJ. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J Rheumatol . 1992;19:604-607.
4 McCarty DJ, Csuka M, McCarthy, et al. Treatment of pain due to fibromyalgia with topical capsaicin: A pilot study. Semin Arthritis Rheum. 1994;23(suppl 3):41-47.
5 Yeoh KG, Kang JY, Yap I, et al. Chili protects against aspirin-induced gastroduodenal mucosal injury in humans. Dig Dis Sci . 1995;40:580-583.
6 Abdel Salam OM, Moszik G, Szolcsanyi J. Studies on the effect of intragastric capsaicin on gastric ulcer and on the prostacyclin-induced cytoprotection in rats. Pharmacol Res. 1995;32:209-215.
7 Holzer P, Pabst MA, Lippe IT. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology. 1989;96:1425-1433.
8 Stander S, Luger T, Metze D. Treatment of prurigo nodularis with topical capsaicin. J Am Acad Dermatol. 2001;44:471-478.
9 Graham DY, Anderson SY, Lang T. Garlic or jalapeno peppers for treatment of Helicobacter pylori infection. Am J Gastroenterol. 1999;94:1200-1202.
10 Rodriguez-Stanley S, Collings KL, Robinson M, et al. The effects of capsaicin on reflux, gastric emptying and dyspepsia. Aliment Pharmacol Ther . 2000;14:129-134.
11 Graham DY, Smith JL, Opekun AR. Spicy food and the stomach. Evaluation by videoendoscopy. JAMA . 1988;260:3473-3475.
12 Bouraoui A, Toumi A, Mustapha HB, et al. Effects of capsicum fruit on theophylline absorption and bioavailability in rabbits. Drug Nutr Interact. 1998;5:345-350.
13 Bortolotti M, Coccia G, Grossi G, et al. The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther . 2002;16:1075-1082.
14 Watson CP, Evans RJ, Watt VR. Post-herpetic neuralgia and topical capsaicin. Pain .1988;33:333-340.
15 Watson CP, Tyler KL, Bickers DR, et al. A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther . 1993;15:510-526.
16 Alper BS, Lewis PR. Treatment of postherpetic neuralgia: a systematic review of the literature. J Fam Pract . 2002;51:121-128.
17 Low PA, Opfer-Gehrking TL, Dyck PJ, et al. Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain . 1995;62:163-168.
18 Biesbroeck R, Bril V, Hollander P, et al. A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy. Adv Ther . 1995;12:111-120.
19 The Capsaicin Study Group. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care . 1992;15:159-165.
20 Tandan R, Lewis GA, Krusinski PB, Badger GB, Fries TJ. Related Articles Topical capsaicin in painful diabetic neuropathy. Controlled study with long-term follow-up. Diabetes Care . 1992;15:8-14.
21 The Capsaicin Study Group. Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. Arch Intern Med . 1991;151:2225-2229.
22 Scheffler NM, Sheitel PL, Lipton MN. Related Articles Treatment of painful diabetic neuropathy with capsaicin 0.075%. J Am Podiatr Med Assoc . 1991; 81:288-293.
23 Jensen PG, Larson JR. Management of painful diabetic neuropathy. Drugs Aging . 2001;18:737-749.
24 Ellison N, Loprinzi CL, Kugler J, et al. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol. 1997;15:2974-2980.
25 Dini D, Bertelli G, Gozza A, et al. Treatment of the post-mastectomy pain syndrome with topical capsaicin. Pain . 1993;54:223-226.
26 Watson CP, Evans RJ. The postmastectomy pain syndrome and topical capsaicin: a randomized trial. Pain . 1992;51:375-379.
27 Watson CP, Evans RJ, Watt VR, et al. The post-mastectomy pain syndrome and the effect of topical capsaicin. Pain . 1989;38:177-186.
28 Todd C. Meeting the therapeutic challenge of the patient with osteoarthritis. J Am Pharm Assoc (Wash). 2002;42:74-82.
29 Marks DR, Rapoport A, Padla D, et al. A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia . 1993;13:114-116.
30 Frerick H, Keitel W, Kuhn U, et al. Topical treatment of chronic low back pain with a capsicum plaster. Pain . 2003;106:59-64.
31 Ellis CN, Berberian B, Sulica VI, et al. A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol . 1993;29:438-442.
32 Bernstein JE, Parish LC, Rapaport M, et al. Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Dermatol . 1986;15:504-507.
33 Reimann S, Luger T, Metze D. Topical administration of capsaicin in dermatology for treatment of itching and pain. Hautarzt. 2000;51:164-172.
34 Altomare DF, Rinaldi M, La Torre F, et al. Red Hot Chili Pepper and Hemorrhoids: The Explosion of a Myth: Results of a Prospective, Randomized Placebo-Controlled Crossover Trial. Dis Colon Rectum . 2006 May 19. [Epub ahead of print]
35 Simpson DM, Brown S, Tobias J. Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy. Neurology. 2008;70:2305-2313.
36 Aasvang EK, Hansen JB, Malmstrom J, et al. The effect of wound instillation of a novel purified capsaicin formulation on postherniotomy pain: a double-blind, randomized, placebo-controlled study. Anesth Analg. 2008;107:282-291.
37 Backonja M, Wallace MS, Blonsky ER, et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol. 2008;7:1106-1112.
38 Ciabatti PG, D'Ascanio L. Intranasal Capsicum spray in idiopathic rhinitis: a randomized prospective application regimen trial. Acta Otolaryngol. 2009;129:367-71.
39 De Silva V, El-Metwally A, Ernst E, Lewith G, Macfarlane GJ. Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology. 2010 Dec 17.
40 Chrubasik S, Weiser T, Beime B. Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain. Phytother Res. 2010;24(12):1877-1885.
41 Bernstein JA, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. Ann Allergy Asthma Immunol. 2011;107(2):171-178.
42 Irving G, Backonja M, et al. NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia. Clin J Pain . 2012;28(2):101-107.
43 Oltean H, Robbins C, et al. Herbal medicine for low-back pain. Cochrane Database Syst Rev. 2014;12:CD004504.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 03/19/2015 -