Principal Proposed Uses
Coenzyme Q 10 (CoQ 10 ), also known as ubiquinone, is a major part of the body's mechanism for producing energy. The name of this supplement comes from the word ubiquitous, which means "found everywhere." Indeed, CoQ 10 is found in every cell in the body. It plays a fundamental role in the mitochondria, the parts of the cell that produce energy from glucose and fatty acids.
Japanese scientists first reported therapeutic properties of CoQ 10 in the 1960s. Some evidence suggests that CoQ 10 might assist the heart during times of stress on the heart muscle, perhaps by helping it use energy more efficiently.
CoQ 10 's best-established use is for congestive heart failure, but the evidence that it works is not entirely consistent. Ongoing research suggests that it may also be useful for other types of heart problems, Parkinson's disease, and several additional illnesses. It is generally used in addition to, rather than instead of, standard therapies.
CoQ 10 supplementation might also be of value for counteracting side effects of certain prescription medications.
Every cell in your body needs CoQ 10 , but there is no dietary requirement as the body can manufacture CoQ 10 from scratch.
The typical recommended dosage of CoQ 10 is 30 mg to 300 mg daily; higher daily intakes have been used in some studies.
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Note: People with severe illnesses, such as heart disease, cancer, or kidney failure, should not use CoQ 10 , or any supplement, except under physician supervision.
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CoQ 10 has additionally been proposed as a treatment for a wide variety of other conditions, including angina , cancer , male infertility , muscular dystrophy, and obesity , but there is, as yet, no evidence that it is effective.
What Is the Scientific Evidence for Coenzyme Q
Congestive Heart Failure
Most but not all studies tell us that CoQ 10 can be helpful for people with congestive heart failure (CHF). In this serious condition, the heart muscles become weakened, resulting in poor circulation and shortness of breath.
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Heart Attack Recovery
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Note: Individuals recovering from a heart attack should not take any herbs or supplements except under the supervision of a physician.
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Further trials will be necessary to confirm (or deny) these results.
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The maximum safe dosages of CoQ 10 for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been determined.
Interactions You Should Know About
You may need more CoQ
if you are taking:
- Cholesterol-lowering drugs in the statin family
- Red yeast rice
- Beta-blockers (specifically propranolol, metoprolol, and alprenolol)
- Antipsychotic drugs in the phenothiazine family
- Tricyclic antidepressants
- Oral diabetes drugs (especially glyburide, phenformin, and tolazamide)
- You should not take CoQ 10 except on a physician's advice if you are taking:
might improve general sense of well-being, but worsen peripheral neuropathy symptoms if you are taking:
- Reverse-transcriptase inhibitors (for HIV infection)
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -