Phenothiazine drugs are primarily used for the treatment of schizophrenia and other forms of psychosis.
Medications in this family include
- Chlorpromazine hydrochloride (Thorazine)
- Fluphenazine (Permitil, Prolixin)
- Mesoridazine besylate (Serentil)
- Perphenazine (Trilafon)
- Prochlorperazine (Compazine)
- Promazine hydrochloride (Sparine)
- Promethazine hydrochloride (Anergan [injectable], Phenergan)
- Thioridazine hydrochloride (Mellaril)
- Trifluoperazine hydrochloride (Stelazine)
- Triflupromazine hydrochloride (Vesprin [injectable])
- and others
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One of the most feared side effects of phenothiazines is the development of a permanent side effect called tardive dyskinesia (TD). This late-developing (tardy, or tardive) complication consists of annoying uncontrollable movements (dyskinesias), particularly in the face.
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Phenothiazines can cause increased sensitivity to the sun. Various herbs, including St. John's wort and dong quai , can also cause this problem. Combined treatment with herb and drug might increase the risk further.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -